Dieses Bild zeigt  Wilhelm K. Aicher

Herr Prof. Dr. rer.nat.

Wilhelm K. Aicher

Laborleiter Tübingen
Eberhard Karls Universität Tübingen
Universitätsklinikum, Klinik für Urologie
[Foto: Wilhelm Aicher, Klinik für Urologie]

Kontakt

+49 7071-29-87020
+49 7071-29-25072

Waldhörnlestraße 22
72072 Tübingen
Deutschland
Raum: ZMF

Items 1-74 of 74 (Display the 74 citations in PubMed)

1.

Stress urinary incontinence and regenerative medicine: is injecting functional cells into the urethra feasible based on current knowledge and future prospects?

Aufderklamm S, Aicher WK, Amend B, Stenzl A.

Curr Opin Urol. 2019 Jul;29(4):394-399. doi: 10.1097/MOU.0000000000000624.

PMID: 31033573Review.

2.

Regenerative medicine and injection therapies in stress urinary incontinence.

Hillary CJ, Roman S, MacNeil S, Aicher WK, Stenzl A, Chapple CR.

Nat Rev Urol. 2020 Mar;17(3):151-161. doi: 10.1038/s41585-019-0273-4. Epub 2020 Jan 23.

PMID: 31974507Review.

3.

Matrix metalloproteinases in stem cell mobilization.

Klein G, Schmal O, Aicher WK.

Matrix Biol. 2015 May-Jul;44-46:175-83. doi: 10.1016/j.matbio.2015.01.011. Epub 2015 Jan 21.

PMID: 25617493Review.

4.

Mesenchymal stromal cells for sphincter regeneration.

Klein G, Hart ML, Brinchmann JE, Rolauffs B, Stenzl A, Sievert KD, Aicher WK.

Adv Drug Deliv Rev. 2015 Mar;82-83:123-36. doi: 10.1016/j.addr.2014.10.026. Epub 2014 Oct 27.

PMID: 25451135Review.

5.

Cell-based therapy for the deficient urinary sphincter.

Hart ML, Neumayer KM, Vaegler M, Daum L, Amend B, Sievert KD, Di Giovanni S, Kraushaar U, Guenther E, Stenzl A, Aicher WK.

Curr Urol Rep. 2013 Oct;14(5):476-87. doi: 10.1007/s11934-013-0352-7.

PMID: 23824516Review.

6.

Regeneration of degenerated urinary sphincter muscles: improved stem cell-based therapies and novel imaging technologies.

Amend B, Vaegler M, Fuchs K, Mannheim JG, Will S, Kramer U, Hart ML, Feitz W, Chapple C, Stenzl A, Aicher WK.

Cell Transplant. 2015;24(11):2171-83. doi: 10.3727/096368915X686229. Epub 2015 Jan 20.

PMID: 25608017Review.

7.

Human Mesenchymal Stromal Cells from Different Sources Diverge in Their Expression of Cell Surface Proteins and Display Distinct Differentiation Patterns.

Elahi KC, Klein G, Avci-Adali M, Sievert KD, MacNeil S, Aicher WK.

Stem Cells Int. 2016;2016:5646384. doi: 10.1155/2016/5646384. Epub 2015 Dec 6.

PMID: 26770208Free PMC article.Review.

8.

Phenotypic and functional heterogeneity of human bone marrow- and amnion-derived MSC subsets.

Sivasubramaniyan K, Lehnen D, Ghazanfari R, Sobiesiak M, Harichandan A, Mortha E, Petkova N, Grimm S, Cerabona F, de Zwart P, Abele H, Aicher WK, Faul C, Kanz L, Bühring HJ.

Ann N Y Acad Sci. 2012 Aug;1266:94-106. doi: 10.1111/j.1749-6632.2012.06551.x.

PMID: 22901261Review.

9.

Towards a Treatment of Stress Urinary Incontinence: Application of Mesenchymal Stromal Cells for Regeneration of the Sphincter Muscle.

Aicher WK, Hart ML, Stallkamp J, Klünder M, Ederer M, Sawodny O, Vaegler M, Amend B, Sievert KD, Stenzl A.

J Clin Med. 2014 Feb 24;3(1):197-215. doi: 10.3390/jcm3010197.

PMID: 26237258Free PMC article.Review.

10.

A novel waterjet technology for transurethral cystoscopic injection of viable cells in the urethral sphincter complex.

Jäger L, Linzenbold W, Fech A, Enderle M, Abruzzese T, Stenzl A, Aicher WK.

Neurourol Urodyn. 2020 Feb;39(2):594-602. doi: 10.1002/nau.24261. Epub 2019 Dec 24.

PMID: 31873953

11.

Labelling and tracking of human mesenchymal stromal cells in preclinical studies and large animal models of degenerative diseases.

Vaegler M, Maerz JK, Amend B, da Silva LA, Mannheim JG, Fuchs K, Will S, Sievert KD, Stenzl A, Hart ML, Aicher WK.

Curr Stem Cell Res Ther. 2014;9(5):444-50. doi: 10.2174/1574888x09666140521144559.

PMID: 24853377Review.

12.

A sensitive refining of in vitro and in vivo toxicological behavior of green synthesized ZnO nanoparticles from the shells of Jatropha curcas for multifunctional biomaterials development.

Suriyaprabha R, Balu KS, Karthik S, Prabhu M, Rajendran V, Aicher WK, Maaza M.

Ecotoxicol Environ Saf. 2019 Nov 30;184:109621. doi: 10.1016/j.ecoenv.2019.109621. Epub 2019 Sep 12.

PMID: 31520953

13.

The spatial organisation of joint surface chondrocytes: review of its potential roles in tissue functioning, disease and early, preclinical diagnosis of osteoarthritis.

Aicher WK, Rolauffs B.

Ann Rheum Dis. 2014 Apr;73(4):645-53. doi: 10.1136/annrheumdis-2013-204308. Epub 2013 Dec 20.

PMID: 24363359Review.

14.

Regeneration of cartilage and bone by defined subsets of mesenchymal stromal cells--potential and pitfalls.

Aicher WK, Bühring HJ, Hart M, Rolauffs B, Badke A, Klein G.

Adv Drug Deliv Rev. 2011 Apr 30;63(4-5):342-51. doi: 10.1016/j.addr.2010.12.004. Epub 2010 Dec 22.

PMID: 21184789Review.

15.

Establishing and monitoring of urethral sphincter deficiency in a large animal model.

Kelp A, Albrecht A, Amend B, Klünder M, Rapp P, Sawodny O, Stenzl A, Aicher WK.

World J Urol. 2017 Dec;35(12):1977-1986. doi: 10.1007/s00345-017-2088-3. Epub 2017 Sep 22.

PMID: 28940030

16.

Expression of Desmoglein 2, Desmocollin 3 and Plakophilin 2 in Placenta and Bone Marrow-Derived Mesenchymal Stromal Cells.

Hart ML, Rusch E, Kaupp M, Nieselt K, Aicher WK.

Stem Cell Rev Rep. 2017 Apr;13(2):258-266. doi: 10.1007/s12015-016-9710-4.

PMID: 28154962

17.

The geometrical shape of mesenchymal stromal cells measured by quantitative shape descriptors is determined by the stiffness of the biomaterial and by cyclic tensile forces.

Uynuk-Ool T, Rothdiener M, Walters B, Hegemann M, Palm J, Nguyen P, Seeger T, Stöckle U, Stegemann JP, Aicher WK, Kurz B, Hart ML, Klein G, Rolauffs B.

J Tissue Eng Regen Med. 2017 Dec;11(12):3508-3522. doi: 10.1002/term.2263. Epub 2017 Mar 29.

PMID: 28371409

18.

Comparative phenotypic transcriptional characterization of human full-term placenta-derived mesenchymal stromal cells compared to bone marrow-derived mesenchymal stromal cells after differentiation in myogenic medium.

Hart ML, Kaupp M, Brun J, Aicher WK.

Placenta. 2017 Jan;49:64-67. doi: 10.1016/j.placenta.2016.11.007. Epub 2016 Nov 16.

PMID: 28012456

19.

Mesenchymal Stromal Cells for Sphincter Regeneration: Role of Laminin Isoforms upon Myogenic Differentiation.

Seeger T, Hart M, Patarroyo M, Rolauffs B, Aicher WK, Klein G.

PLoS One. 2015 Sep 25;10(9):e0137419. doi: 10.1371/journal.pone.0137419. eCollection 2015.

PMID: 26406476 Free PMC article.

20.

Human Placenta-Derived CD146-Positive Mesenchymal Stromal Cells Display a Distinct Osteogenic Differentiation Potential.

Ulrich C, Abruzzese T, Maerz JK, Ruh M, Amend B, Benz K, Rolauffs B, Abele H, Hart ML, Aicher WK.

Stem Cells Dev. 2015 Jul 1;24(13):1558-69. doi: 10.1089/scd.2014.0465. Epub 2015 Apr 13.

PMID: 25743703

21.

Choice of xenogenic-free expansion media significantly influences the myogenic differentiation potential of human bone marrow-derived mesenchymal stromal cells.

Brun J, Abruzzese T, Rolauffs B, Aicher WK, Hart ML.

Cytotherapy. 2016 Mar;18(3):344-59. doi: 10.1016/j.jcyt.2015.11.019.

PMID: 26857228

22.

Bone marrow-derived mesenchymal stromal cells differ in their attachment to fibronectin-derived peptides from term placenta-derived mesenchymal stromal cells.

Maerz JK, Roncoroni LP, Goldeck D, Abruzzese T, Kalbacher H, Rolauffs B, DeZwart P, Nieselt K, Hart ML, Klein G, Aicher WK.

Stem Cell Res Ther. 2016 Feb 11;7:29. doi: 10.1186/s13287-015-0243-6.

PMID: 26869043 Free PMC article.

23.

Precise injection of human mesenchymal stromal cells in the urethral sphincter complex of Göttingen minipigs without unspecific bulking effects.

Amend B, Kelp A, Vaegler M, Klünder M, Frajs V, Klein G, Sievert KD, Sawodny O, Stenzl A, Aicher WK.

Neurourol Urodyn. 2017 Sep;36(7):1723-1733. doi: 10.1002/nau.23182. Epub 2016 Dec 9.

PMID: 27935100

24.

Stretching human mesenchymal stromal cells on stiffness-customized collagen type I generates a smooth muscle marker profile without growth factor addition.

Rothdiener M, Hegemann M, Uynuk-Ool T, Walters B, Papugy P, Nguyen P, Claus V, Seeger T, Stoeckle U, Boehme KA, Aicher WK, Stegemann JP, Hart ML, Kurz B, Klein G, Rolauffs B.

Sci Rep. 2016 Oct 24;6:35840. doi: 10.1038/srep35840.

PMID: 27775041 Free PMC article.

25.

Processing of CXCL12 by different osteoblast-secreted cathepsins.

Staudt ND, Maurer A, Spring B, Kalbacher H, Aicher WK, Klein G.

Stem Cells Dev. 2012 Jul 20;21(11):1924-35. doi: 10.1089/scd.2011.0307. Epub 2012 Jan 4.

PMID: 22066471 Free PMC article.

26.

Osteoclast-independent bone resorption by fibroblast-like cells.

Pap T, Claus A, Ohtsu S, Hummel KM, Schwartz P, Drynda S, Pap G, Machner A, Stein B, George M, Gay RE, Neumann W, Gay S, Aicher WK.

Arthritis Res Ther. 2003;5(3):R163-73. doi: 10.1186/ar752. Epub 2003 Mar 26.

PMID: 12723988 Free PMC article.

27.

Human mesenchymal stromal cells express CD14 cross-reactive epitopes.

Pilz GA, Braun J, Ulrich C, Felka T, Warstat K, Ruh M, Schewe B, Abele H, Larbi A, Aicher WK.

Cytometry A. 2011 Aug;79(8):635-45. doi: 10.1002/cyto.a.21073. Epub 2011 Jul 6.

PMID: 21735544

28.

Identification of an aptamer binding to human osteogenic-induced progenitor cells.

Ardjomandi N, Niederlaender J, Aicher WK, Reinert S, Schweizer E, Wendel HP, Alexander D.

Nucleic Acid Ther. 2013 Feb;23(1):44-61. doi: 10.1089/nat.2012.0349. Epub 2013 Jan 4.

PMID: 23289534 Free PMC article.

29.

Maintenance of "stem cell" features of cartilage cell sub-populations during in vitro propagation.

Benz K, Stippich C, Freudigmann C, Mollenhauer JA, Aicher WK.

J Transl Med. 2013 Jan 30;11:27. doi: 10.1186/1479-5876-11-27.

PMID: 23363653 Free PMC article.

30.

Hematopoietic Stem and Progenitor Cell Expansion in Contact with Mesenchymal Stromal Cells in a Hanging Drop Model Uncovers Disadvantages of 3D Culture.

Schmal O, Seifert J, Schäffer TE, Walter CB, Aicher WK, Klein G.

Stem Cells Int. 2016;2016:4148093. doi: 10.1155/2016/4148093. Epub 2015 Dec 29.

PMID: 26839560 Free PMC article.

31.

Smooth Muscle-Like Cells Generated from Human Mesenchymal Stromal Cells Display Marker Gene Expression and Electrophysiological Competence Comparable to Bladder Smooth Muscle Cells.

Brun J, Lutz KA, Neumayer KM, Klein G, Seeger T, Uynuk-Ool T, Wörgötter K, Schmid S, Kraushaar U, Guenther E, Rolauffs B, Aicher WK, Hart ML.

PLoS One. 2015 Dec 16;10(12):e0145153. doi: 10.1371/journal.pone.0145153. eCollection 2015.

PMID: 26673782 Free PMC article.

32.

Onset of preclinical osteoarthritis: the angular spatial organization permits early diagnosis.

Rolauffs B, Rothdiener M, Bahrs C, Badke A, Weise K, Kuettner KE, Kurz B, Aurich M, Grodzinsky AJ, Aicher WK.

Arthritis Rheum. 2011 Jun;63(6):1637-47. doi: 10.1002/art.30217.

PMID: 21630246

33.

Generation of pluripotent stem cells from adult human testis.

Conrad S, Renninger M, Hennenlotter J, Wiesner T, Just L, Bonin M, Aicher W, Bühring HJ, Mattheus U, Mack A, Wagner HJ, Minger S, Matzkies M, Reppel M, Hescheler J, Sievert KD, Stenzl A, Skutella T.

Nature. 2008 Nov 20;456(7220):344-9. doi: 10.1038/nature07404. Epub 2008 Oct 8.

PMID: 18849962 Retracted.

34.

Hydrojet-based delivery of footprint-free iPSC-derived cardiomyocytes into porcine myocardium.

Weber M, Fech A, Jäger L, Steinle H, Bühler L, Perl RM, Martirosian P, Mehling R, Sonanini D, Aicher WK, Nikolaou K, Schlensak C, Enderle MD, Wendel HP, Linzenbold W, Avci-Adali M.

Sci Rep. 2020 Oct 8;10(1):16787. doi: 10.1038/s41598-020-73693-x.

PMID: 33033281 Free PMC article.

35.

Bisphosphonates modulate vital functions of human osteoblasts and affect their interactions with breast cancer cells.

Kaiser T, Teufel I, Geiger K, Vater Y, Aicher WK, Klein G, Fehm T.

Breast Cancer Res Treat. 2013 Jul;140(1):35-48. doi: 10.1007/s10549-013-2613-z. Epub 2013 Jun 27.

PMID: 23807419

36.

Release of matrix metalloproteinase-8 during physiological trafficking and induced mobilization of human hematopoietic stem cells.

Steinl C, Essl M, Schreiber TD, Geiger K, Prokop L, Stevanović S, Pötz O, Abele H, Wessels JT, Aicher WK, Klein G.

Stem Cells Dev. 2013 May 1;22(9):1307-18. doi: 10.1089/scd.2012.0063. Epub 2013 Feb 12.

PMID: 23259856 Free PMC article.

37.

Animal serum-free expansion and differentiation of human mesenchymal stromal cells.

Felka T, Schäfer R, De Zwart P, Aicher WK.

Cytotherapy. 2010 Apr;12(2):143-53. doi: 10.3109/14653240903470647.

PMID: 20141338

38.

Biomimetic TiO2-chitosan/sodium alginate blended nanocomposite scaffolds for tissue engineering applications.

Kolathupalayam Shanmugam B, Rangaraj S, Subramani K, Srinivasan S, Aicher WK, Venkatachalam R.

Mater Sci Eng C Mater Biol Appl. 2020 May;110:110710. doi: 10.1016/j.msec.2020.110710. Epub 2020 Jan 31.

PMID: 32204022

39.

Osteoblast-secreted factors enhance the expression of dysadherin and CCL2-dependent migration of renal carcinoma cells.

Schüler Y, Lee-Thedieck C, Geiger K, Kaiser T, Ino Y, Aicher WK, Klein G.

Int J Cancer. 2012 Jan 15;130(2):288-99. doi: 10.1002/ijc.25981. Epub 2011 Apr 1.

PMID: 21328336

40.

TGF-beta enhances the integrin alpha2beta1-mediated attachment of mesenchymal stem cells to type I collagen.

Warstat K, Meckbach D, Weis-Klemm M, Hack A, Klein G, de Zwart P, Aicher WK.

Stem Cells Dev. 2010 May;19(5):645-56. doi: 10.1089/scd.2009.0208.

PMID: 19827952

41.

Laminin-5 and type I collagen promote adhesion and osteogenic differentiation of animal serum-free expanded human mesenchymal stromal cells.

Mittag F, Falkenberg EM, Janczyk A, Götze M, Felka T, Aicher WK, Kluba T.

Orthop Rev (Pavia). 2012 Dec 11;4(4):e36. doi: 10.4081/or.2012.e36. Print 2012 Nov 2.

PMID: 23589764 Free PMC article.

42.

Rheological and biological properties of a hydrogel support for cells intended for intervertebral disc repair.

Benz K, Stippich C, Osswald C, Gaissmaier C, Lembert N, Badke A, Steck E, Aicher WK, Mollenhauer JA.

BMC Musculoskelet Disord. 2012 Apr 10;13:54. doi: 10.1186/1471-2474-13-54.

PMID: 22490206 Free PMC article.

43.

Low osteogenic differentiation potential of placenta-derived mesenchymal stromal cells correlates with low expression of the transcription factors Runx2 and Twist2.

Ulrich C, Rolauffs B, Abele H, Bonin M, Nieselt K, Hart ML, Aicher WK.

Stem Cells Dev. 2013 Nov 1;22(21):2859-72. doi: 10.1089/scd.2012.0693. Epub 2013 Jul 20.

PMID: 23763516 Free PMC article.

44.

Supramolecular conjugates of carbon nanotubes and DNA by a solid-state reaction.

Nepal D, Sohn JI, Aicher WK, Lee S, Geckeler KE.

Biomacromolecules. 2005 Nov-Dec;6(6):2919-22. doi: 10.1021/bm050380m.

PMID: 16283707

45.

DOCA and TGF-beta induce early growth response gene-1 (Egr-1) expression.

Friedrich B, Janessa A, Artunc F, Aicher WK, Müller GA, Lang F, Risler T, Alexander D.

Cell Physiol Biochem. 2008;22(5-6):465-74. doi: 10.1159/000185495. Epub 2008 Dec 9.

PMID: 19088428

46.

Stress-vs-time signals allow the prediction of structurally catastrophic events during fracturing of immature cartilage and predetermine the biomechanical, biochemical, and structural impairment.

Rolauffs B, Kurz B, Felka T, Rothdiener M, Uynuk-Ool T, Aurich M, Frank E, Bahrs C, Badke A, Stöckle U, Aicher WK, Grodzinsky AJ.

J Struct Biol. 2013 Sep;183(3):501-511. doi: 10.1016/j.jsb.2013.06.011. Epub 2013 Jun 28.

PMID: 23810923 Free PMC article.

47.

Human term placenta-derived mesenchymal stromal cells are less prone to osteogenic differentiation than bone marrow-derived mesenchymal stromal cells.

Pilz GA, Ulrich C, Ruh M, Abele H, Schäfer R, Kluba T, Bühring HJ, Rolauffs B, Aicher WK.

Stem Cells Dev. 2011 Apr;20(4):635-46. doi: 10.1089/scd.2010.0308. Epub 2011 Jan 27.

PMID: 21047215

48.

Evaluation of the osteogenic and chondrogenic differentiation capacities of equine adipose tissue-derived mesenchymal stem cells.

Braun J, Hack A, Weis-Klemm M, Conrad S, Treml S, Kohler K, Walliser U, Skutella T, Aicher WK.

Am J Vet Res. 2010 Oct;71(10):1228-36. doi: 10.2460/ajvr.71.10.1228.

PMID: 20919912

49.

Cartilage destruction mediated by synovial fibroblasts does not depend on proliferation in rheumatoid arthritis.

Seemayer CA, Kuchen S, Kuenzler P, Rihosková V, Rethage J, Aicher WK, Michel BA, Gay RE, Kyburz D, Neidhart M, Gay S.

Am J Pathol. 2003 May;162(5):1549-57. doi: 10.1016/S0002-9440(10)64289-7.

PMID: 12707039 Free PMC article.

50.

Induction of endostatin expression in meniscal fibrochondrocytes by co-culture with endothelial cells.

Hoberg M, Schmidt EL, Tuerk M, Stark V, Aicher WK, Rudert M.

Arch Orthop Trauma Surg. 2009 Aug;129(8):1137-43. doi: 10.1007/s00402-008-0766-8. Epub 2008 Oct 7.

PMID: 18839188

51.

Rapid and precise delivery of cells in the urethral sphincter complex by a novel needle-free waterjet technology.

Linzenbold W, Jäger L, Stoll H, Abruzzese T, Harland N, Bézière N, Fech A, Enderle M, Amend B, Stenzl A, Aicher WK.

BJU Int. 2020 Sep 17. doi: 10.1111/bju.15249. Online ahead of print.

PMID: 32940408

52.

Characterization and functional analysis of osteoblast-derived fibulins in the human hematopoietic stem cell niche.

Hergeth SP, Aicher WK, Essl M, Schreiber TD, Sasaki T, Klein G.

Exp Hematol. 2008 Aug;36(8):1022-34. doi: 10.1016/j.exphem.2008.03.013. Epub 2008 May 12.

PMID: 18468769

53.

Interleukin-18 is regulated by G protein pathways and protein kinase signals in human fibroblasts.

Schuler MK, Aicher WK.

Rheumatol Int. 2004 Jan;24(1):1-8. doi: 10.1007/s00296-003-0321-4. Epub 2003 Jul 15.

PMID: 12879265

54.

The integrin alpha9beta1 on hematopoietic stem and progenitor cells: involvement in cell adhesion, proliferation and differentiation.

Schreiber TD, Steinl C, Essl M, Abele H, Geiger K, Müller CA, Aicher WK, Klein G.

Haematologica. 2009 Nov;94(11):1493-501. doi: 10.3324/haematol.2009.006072. Epub 2009 Jul 16.

PMID: 19608669 Free PMC article.

55.

Enhanced biocompatibility for SAOS-2 osteosarcoma cells by surface coating with hydrophobic epoxy resins.

Geckeler K, Wacker R, Martini F, Hack A, Aicher W.

Cell Physiol Biochem. 2003;13(3):155-64. doi: 10.1159/000071866.

PMID: 12876386

56.

Risk assessment of neuromuscular stimulation by energy-based transurethral resection devices: an ex vivo test standard.

Biber U, Jurjut O, Enderle MD, Aicher WK.

BMC Urol. 2020 May 27;20(1):59. doi: 10.1186/s12894-020-00630-5.

PMID: 32460737 Free PMC article.

57.

Author Correction: Regenerative medicine and injection therapies in stress urinary incontinence.

Hillary CJ, Roman S, MacNeil S, Aicher WK, Stenzl A, Chapple CR.

Nat Rev Urol. 2020 Nov;17(11):650. doi: 10.1038/s41585-020-0340-x.

PMID: 32457430

58.

Attachment to laminin-111 facilitates transforming growth factor beta-induced expression of matrix metalloproteinase-3 in synovial fibroblasts.

Hoberg M, Rudert M, Pap T, Klein G, Gay S, Aicher WK.

Ann Rheum Dis. 2007 Apr;66(4):446-51. doi: 10.1136/ard.2006.060228. Epub 2006 Nov 23.

PMID: 17124250 Free PMC article.

59.

The active form of leflunomide, HMR1726, facilitates TNF-alpha and IL-17 induced MMP-1 and MMP-3 expression.

Alexander D, Friedrich B, Abruzzese T, Gondolph-Zink B, Wülker N, Aicher WK.

Cell Physiol Biochem. 2006;17(1-2):69-78. doi: 10.1159/000091465. Epub 2006 Feb 7.

PMID: 16543723

60.

Comparison of marker gene expression in chondrocytes from patients receiving autologous chondrocyte transplantation versus osteoarthritis patients.

Stoop R, Albrecht D, Gaissmaier C, Fritz J, Felka T, Rudert M, Aicher WK.

Arthritis Res Ther. 2007;9(3):R60. doi: 10.1186/ar2218.

PMID: 17596264 Free PMC article.

61.

Toll-like receptor engagement enhances the immunosuppressive properties of human bone marrow-derived mesenchymal stem cells by inducing indoleamine-2,3-dioxygenase-1 via interferon-beta and protein kinase R.

Opitz CA, Litzenburger UM, Lutz C, Lanz TV, Tritschler I, Köppel A, Tolosa E, Hoberg M, Anderl J, Aicher WK, Weller M, Wick W, Platten M.

Stem Cells. 2009 Apr;27(4):909-19. doi: 10.1002/stem.7.

PMID: 19353519

62.

Cathepsin X is secreted by human osteoblasts, digests CXCL-12 and impairs adhesion of hematopoietic stem and progenitor cells to osteoblasts.

Staudt ND, Aicher WK, Kalbacher H, Stevanovic S, Carmona AK, Bogyo M, Klein G.

Haematologica. 2010 Sep;95(9):1452-60. doi: 10.3324/haematol.2009.018671. Epub 2010 May 21.

PMID: 20494937 Free PMC article.

63.

Remodeling of articular cartilage and subchondral bone after bone grafting and matrix-associated autologous chondrocyte implantation for osteochondritis dissecans of the knee.

Ochs BG, Müller-Horvat C, Albrecht D, Schewe B, Weise K, Aicher WK, Rolauffs B.

Am J Sports Med. 2011 Apr;39(4):764-73. doi: 10.1177/0363546510388896. Epub 2010 Dec 30.

PMID: 21193592

64.

Transcription factor early growth response 1 activity up-regulates expression of tissue inhibitor of metalloproteinases 1 in human synovial fibroblasts.

Aicher WK, Alexander D, Haas C, Kuchen S, Pagenstecher A, Gay S, Peter HH, Eibel H.

Arthritis Rheum. 2003 Feb;48(2):348-59. doi: 10.1002/art.10774.

PMID: 12571843

65.

Transcription factor Egr-1 activates collagen expression in immortalized fibroblasts or fibrosarcoma cells.

Alexander D, Judex M, Meyringer R, Weis-Klemm M, Gay S, Müller-Ladner U, Aicher WK.

Biol Chem. 2002 Dec;383(12):1845-53. doi: 10.1515/BC.2002.208.

PMID: 12553721

66.

Synovial fibroblasts from rheumatoid arthritis patients differ in their regulation of IL-16 gene activity in comparison to osteoarthritis fibroblasts.

Weis-Klemm M, Alexander D, Pap T, Schützle H, Reyer D, Franz JK, Aicher WK.

Cell Physiol Biochem. 2004;14(4-6):293-300. doi: 10.1159/000080339.

PMID: 15319533

67.

Bone morphogenetic protein (BMP)-2 enhances the expression of type II collagen and aggrecan in chondrocytes embedded in alginate beads.

Gründer T, Gaissmaier C, Fritz J, Stoop R, Hortschansky P, Mollenhauer J, Aicher WK.

Osteoarthritis Cartilage. 2004 Jul;12(7):559-67. doi: 10.1016/j.joca.2004.04.001.

PMID: 15219571

68.

Influence of standard haemodialysis treatment on transcription of human serum- and glucocorticoid-inducible kinase SGK1 and taurine transporter TAUT in blood leukocytes.

Friedrich B, Alexander D, Aicher WK, Duszenko M, Schaub TP, Passlick-Deetjen J, Waldegger S, Wolf S, Risler T, Lang F.

Nephrol Dial Transplant. 2005 Apr;20(4):768-74. doi: 10.1093/ndt/gfh697. Epub 2005 Feb 8.

PMID: 15701671

69.

Modeling chondrocyte patterns by elliptical cluster processes.

Meinhardt M, Lück S, Martin P, Felka T, Aicher W, Rolauffs B, Schmidt V.

J Struct Biol. 2012 Feb;177(2):447-58. doi: 10.1016/j.jsb.2011.11.023. Epub 2011 Dec 1.

PMID: 22155191

70.

Ribozymes that inhibit the production of matrix metalloproteinase 1 reduce the invasiveness of rheumatoid arthritis synovial fibroblasts.

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Akademische Ausbildung und beruflicher Werdegang

  • 1980 - 1985 Studies in Biochemistry and Physiological Chemistry at the University of Tübingen and at Ludwigs-Maximilians University, Munich
  • 1985 - 1986 Diploma Thesis, University of Tübingen and Max-Planck Institute for Developmental Biology, Tübingen
  • 1986 - 1989 PhD student at Max-Planck Institute for Biology, Tübingen
  • 1987 - 1989 Research Fellow, Department of Microbiology, University of Alabama at Birmingham (UAB), Birmingham, AL. USA
  • 1990 PhD, Faculty of Biology at University of Tübingen
  • 1990 - 1991Research Associate, Division of Rheumatology, WHO Rheumatology Research Center at UAB, Birmingham, AL. USA
  • 1992 - 1996 Research Assistant, Clinical Rheumatology Research Group University of Freiburg Hospital, Freiburg
  • 1997 - 2011 Head of Research Laboratory, Dept. of Orthopopedic Surgery University of Tübingen Hospital, Tübingen
  • 1999 Habilitation and venia legendi at Faculty of Medicine, Eberhard-Karls University, Tübingen
  • 2005 - 2013 Assoc. Prof. for Molecular Medicine (apl. Prof.), Centre for Medical Research, University of Tübingen Medical School 2006 - 2011 Deputy Director, Centre for Regeneration Biology and Medical Technology, at University of Tübingen
  • 2006 - 2011 Deputy Director, Centre for Regeneration Biology and Medical Technology, at University of Tübingen
  • 2012 - 2015 Head of KFO273, Medical Faculty, Eberhard-Karls University, Tübingen
  • 2013 - 2017 Coordinator of COST Action BM1209 Regenerative Sphincter Therapy ( ReST
  • 2014 - present Professor for Experimental Urology, Head of Research Laboratories, Dept. of Urology, University of Tübingen Hospital
  • 2017 - 2020 Management Committee, COST Action ENIUS; file # CA16217) 
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